Angewandte Chemie, Accepted Article.
Saturated mimetics for ortho ‐disubstituted benzenes ‐ bicyclo[2.1.1]hexanes, ‐ were synthesized, characterized and validated. These cores were incorporated into bioactive compounds Valsartan, Boskalid and Fluxapyroxad instead of the benzene ring. The saturated analogues showed a similar level of antifungal activity compared to that of Boskalid and Fluxapyroxad .